The Role of Homer Scaffolding to Metabotropic Glutamate Receptor 5 in Mouse Models of Neurodevelopmental Disorders
From Jeff Layne on October 31st, 2016
Faculty, Department of Biological Sciences,
By studying behavior in mice, Dr. Katie Collins hopes to learn more about Fragile X syndrome in humans. Fragile X is the most common inherited form of intellectual disability in humans, affecting one out of every 4,000 males. It is a leading genetic cause of autism; those with the disease also have lower cognitive abilities (IQs of 40-70), sensory hypersensitivity, and epilepsy (about 20% of individuals). Dr. Collins’ research has focused on “mGluR5- homer,” which is the binding protein that acts as a scaffold and signaling molecule. She and other researchers hypothesize that disruptions to this scaffolding protein contribute to Fragile X syndrome.
Recorded: September 19, 2014